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Prevalence 22 cases per million4,*
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Annual New Cases 2.4 per million4,*
*True incidence and prevalence rates for CD in the United States are unknown. Estimated data are pooled rates based on a meta-analysis of global CD epidemiology.4
Cushing’s disease (CD) is a rare hormonal disorder caused by a pituitary adenoma that secretes excess adrenocorticotropic hormone (ACTH).5,6 Excess ACTH stimulates the adrenal glands to overproduce cortisol, leading to the clinical manifestations of CD.5
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Prevalence ≈25,0007
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Annual New Cases 3,0007
Often referred to as somatotroph adenoma or growth hormone excess, acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone.8
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REFERENCES: 1. Papoian V, Biller BMK, Webb SM, et al. Patients’ perception on clinical outcome and quality of life after a diagnosis of Cushing syndrome. Endocr Pract. 2016;22(1):51-67. doi:10.4158/EP15855.OR. 2. Sharma ST, Nieman LK, Feelders RA. Cushing’s syndrome: epidemiology and developments in disease management. Clin Epidemiol. 2015;17(7):281-293. doi:10.2147/CLEP. S44336. 3. Zahr R, Fleseriu M. Updates in Diagnosis and Treatment of Acromegaly. Eur J Endocrinol. 2018;14(2):57–61. doi: 10.17925/EE.2018.14.2.57. 4. Giuffrida G, Crisafulli S, Ferraù F, et al. Global Cushing’s disease epidemiology: a systematic review and meta-analysis of observational studies. J Endocrinol Invest. 2022 Jun;45(6):1235-1246. doi: 10.1007/s40618-022-01754-1. 5. Geer EB, Shafiq I, Gordon MB, et al. Biochemical control during long-term follow-up of 230 adult patients with Cushing disease: a multicenter retrospective study. Endocr Pract. 2017;23(8):962-970. doi: 10.4158/EP171787.OR. 6. Dekkers OM, Horváth-Puhó E, Jørgensen JOL, et al. Multisystem morbidity and mortality in Cushing’s syndrome: a cohort study. J Clin Endocrinol Metab. 2013;98(6):2277-2284. doi: 10.1210/jc.2012-3582. 7. Broder MS, Chang E, Cherepanov D, Neary MP, Ludlam WH. Incidence and Prevalence of Acromegaly in the United States: A Claims-Based Analysis. Endocr Pract. 2016 Nov;22(11):1327-1335. doi: 10.4158/EP161397.OR. 8. What is Acromegaly? UCLA Health. Accessed August 23, 2022. https://www.uclahealth.org/medical-services/surgery/endocrine-surgery/patient-resources/patient-education/endocrine-surgery-encyclopedia/acromegaly.