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KnowRareEndo

Featuring clinical data on rare endocrine disorders, KnowRareEndo provides information and resources to help guide you in the identification, diagnosis and treatment of both Cushing's syndrome and acromegaly.

34

Average time in months to a Cushing's syndrome diagnosis, based on a comprehensive meta-analysis involving 5,367 patients across various subtypes of the syndrome.1

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10-11

Estimated number of years acromegaly symptoms have been present, due to delay in diagnosis.2

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Cushing’s Syndrome
  • Prevalence 57 cases per million3,a
  • Annual New Cases 3.2 per million3,a

Endogenous Cushing's syndrome (CS) is a serious endocrine disease caused by elevated cortisol levels (hypercortisolemia), putting patients at risk for potential life-threatening comorbidities.4

aTrue incidence and prevalence rates of CS in the United States are unknown. Estimated data are based on a retrospective study using a regional health registry in Sweden.3

Acromegaly
  • Prevalence ≈25,0005
  • Annual New Cases 3,0005

Often referred to as somatotroph adenoma or growth hormone excess, acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone.6

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REFERENCES: 1. Rubinstein G, Osswald A, Hoster E, et al. Time to diagnosis in Cushing’s syndrome: A meta-analysis based on 5367 patients. J Clin Endocrinol Metab. 2020;105(3):dgz136. doi:10.1210/clinem/dgz136. 2. Zahr R, Fleseriu M. Updates in Diagnosis and Treatment of Acromegaly. Eur J Endocrinol. 2018;14(2):57–61. doi: 10.17925/EE.2018.14.2.57. 3. Wengander S, Trimpou P, Papakokkinou E, Ragnarsson O. The incidence of endogenous Cushing’s syndrome in the modern era. Clin Endocrinol (Oxf). 2019;91(2):263-270. doi:10.1111/cen.14014. 4. Pivonello R, Isidori AM, De Martino MC, Newell-Price J, Biller BM, Colao A. Complications of Cushing’s syndrome: state of the art. Lancet Diabetes Endocrinol. 2016;4(7):611-629. doi:10.1016/S2213-8587(16)00086-3. 5. Broder MS, Chang E, Cherepanov D, Neary MP, Ludlam WH. Incidence and Prevalence of Acromegaly in the United States: A Claims-Based Analysis. Endocr Pract. 2016 Nov;22(11):1327-1335. doi: 10.4158/EP161397.OR. 6. What is Acromegaly? UCLA Health. Accessed August 23, 2022. https://www.uclahealth.org/medical-services/surgery/endocrine-surgery/patient-resources/patient-education/endocrine-surgery-encyclopedia/acromegaly.